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Prof. Dr. med. Claus Ulrich Niederau

Prof. Dr. med.
Claus Ulrich Niederau

Facharzt für Innere Medizin

Diabetologie, Gastroenterologie

  • Chefarzt Klinik für Innere Medizin

St. Josef-Hospital

Mülheimer Str. 83
46045 Oberhausen

Behandlungsrelevante Informationen

Ärztliche Ausbildung

  • Facharzt-Ausbildung im Bereich Innere Medizin
  • Schwerpunkte: Gastroenterologie
  • Zusatzqualifikationen: Diabetologie



Wissenschaftliche Informationen


  • Virushepatitis, Hämochromatose, M. Wilson, M. Gaucher, Pankreaserkarnkungen, Crohn, Colitis, GI-Hormone

Mitglied in folgenden Fachgesellschaften

  • American Gastroenterological Association (AGA)
  • Deutsche Diabetes Gesellschaft (DDG)
  • Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)

Wissenschaftliche Preise

  • Klinische Gastroenterologie (DGVS), AGA Forschungspreis


  • 1979: Titel „Peptid-PABA Test bei exokriner Pankreasinsuffizienz“


  • 1988: Untersuchungen zu Pathophysiologie, Diagnostik und Therapie der akuten Pankreatitis

Ausgewählte Publikationen

  • Heintges T, Niederau C, Goertz G, Strohmeyer G - Interferon treatment causes deterioration of lichen ruber planus but not of acute intermittent porphyria. Journal of Hepatology 11/1994 1151-1153
  • Niederau C, Sonnenberg A, Müller J, Erckenbrecht J, Scholten T, Fritsch WP: - Sonographic measurements of normal liver, spleen, pancreas, and portal vein. . Radiology 06/1983 537-540
  • Niederau C, Sonnenberg A, Müller J: - Liver size evaluated by ultrasound: ROC curves for hepatitis and alcoholism. Gastroenterology 06/1984 503-505
  • Niederau C, Ferrell LD, Grendell JH - Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Gastroenterology 01/1985 1192-1204
  • Niederau C, Grendell JH - Intracellular vacuoles in experimental acute pancreatitis are an acidified compartment. Journal of Clinical investigation 01/1988
  • Niederau C, Crass RA, Silver J, Ferrell LD, Grendell JH - Effects of hydration, oxygenation, peritoneal lavage, and a new protease inhibitor on experimental acute pancreatitis. Gastroenterology 10/1988 1648-1657
  • Niederau C, Heintges T, Rovati L, Strohmeyer G - Effects of loxiglumide on gallbladder emptying after a meal or after intravenous infusion of caerulein in healthy human volunteers. Gastroenterology 08/1989 1331-1337
  • Niederau C, Lüthen R, Niederau M, Strohmeyer G, Ferrell LD, Grendell JH - Pancreatic exocrine secretion in acute experimental pancreatitis. Gastroenterology 02/1990 1120-1127
  • Niederau C, Grendell JH - Diagnosis of chronic pancreatitis. Gastroenterology 03/1985 1973-1995
  • Niederau C, Grendell JH - Diagnosis of pancreatic carcinoma. Pancreas 04/1991 282-290
  • Niederau C, Karaus M - Cholecystokinin's role in regulation of colonic motility in health and in irritable bowel syndrome. Gastroenterology 06/1992 1889-1998
  • Niederau C - The effects of CCK on pancreatic function and morphology. Annals of the New York Academy of Sciences 10/1994 180-196
  • Niederau C, Littauer A, Strohmeyer G - Glucocerebrosidase for treatment of Gaucher's disease. Journal of Hepatology 02/1994 610-617
  • Niederau C, Pohlmann U, Lübke H, Thomas L - Prophylactic antibiotic treatment in herapeutic or complicated diagnostic ERCP: results of a randomized controlled clinical study. Gastrointestinal Endoscopy 03/1994 533-537
  • Niederau C, Fischer R, Pürschel A, Stremmel W, Häussinger D, Strohmeyer G - Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 05/1996 1007-1019
  • Niederau C, Heintges T, Lange S. Goldmann G, Niederau C, Mohr L, Häussinger D - Long-term survival in patients with hereditary hemochromatosis. . New England Journal of Medicine 04/1996 1422-1427
  • Niederau C - Iron overload and atherosclerosis. Hepatology 05/2000 569-574
  • Niederau C, Hippenstiel C - Conservative management of acute pancreatitis: complications and outcome in a community-based hospital. Pancreas 01/2006 67-79
  • Niederau C, Lange S, Frühauf M, Thiel A - Cutaneous signs of liver disease: value for prognosis of severe fibrosis and cirrhosis. Liver International 04/2008 659-666
  • Niederau C, Hüppe D, Zehnter E, Möller B, Heyne R, Christensen S, Pfaff R, Theilmeier A, Alshuth U, Mauss S - Chronic hepatitis C: treat of wait? Medical decision making in clinical practice. World Journal of gastroenterology 03/2012 55-65
  • Niederau C, Mauss S, Böker K, Lutz T, Heyne R, Moog G, John C, Witthöft T, Alshuth U, Hüppe D. - Non-compliance with guidelines for treatment of hepatitis C is frequent in daily practice. European Journal of Gastroenterology and Hepatology 01/2014 65-73
  • Sonnenberg A, Erckenbrecht J, Peter P, Niederau C - Detection of Crohn's disease by ultrasound. Gastroenterology 03/1982 430-434
  • Thienhaus R, Niederau C, Tennie U - Exocrine pancreatic insufficiency. Chymotrypsin determination and peptide PABA test. Deutsche Medizinische Wochenschrift 02/1978 1358-1360
  • Kley HK, Stremmel W, Niederau C, Hehrmann R, Shams O, Strohmeyer G, Krüskemper HL - Androgen and estrogen response to adrenal and gonadal stimulation in idiopa¬thic hemochromatosis: evidence for decreased estrogen formation. Hepatology 07/1985 251-256
  • Stremmel W, Meyerrose KW, Niederau C, Strohmeyer G - Diagnosis, treatment, and prognosis of Wilson's disease: Evaluation of 52 patients. Annals of Internal Medicine 05/1991 720-726
  • Niederau C, Van Dyke RW, Scharschmidt BF, Grendell JH - Rat pancreatic zymogen granules: an actively acidified compartment.. Gastroenterology 07/1986 1433-1442
  • Niederau C, Liddle RA, Williams JA, Grendell JH - Pancreatic growth: interaction of exogenous chole-cystokinin, a protease inhibitor, and a cholecystokinin re¬ceptor antagonist in mice. Gut 04/1997
  • Niederau C, Lange S, Heintges T, Erhardt A, Buschkamp M, Hurter D, Nawrocki M, Kruska L, Hensel F, Petry W, Haussinger D - Prognosis of chronic hepatitis C: results of a large, prospective cohort study. Hepatology 07/1998 1687-1695
  • Niederau C, Niederau CM, Lange S, Littauer A, Abdel-Jalil N, Maurer M, Haussinger D, Strohmeyer G - Screening for hemochromatosis and iron deficiency in employees and primary care patients in Western Germany. Annals of Internal Medicine 03/1998 337-345
  • Lüthen R, Ferrell LD, Grendell JH, Niederau C - Subcellular distribution of pancreatic digestive and lysosomal enzymes in experimental acute pancreatitis. Gastroenterology 12/1995 573-581
  • von Herbay A, Stahl W, Niederau C, von Laar J, Strohmeyer G, Sies H - Diminished plasma levels of vitamin E in patients with severe viral hepatitis. Free Radical Research 05/1996 461-466
  • Klonowski-Stumpe H, Schreiber R, Grolik M, Schulz HU, Haussinger D, Niederau C - Effect of oxidative stress on cellular functions and cytosolic free calcium of rat pancreatic acinar cells. American Journal of Physiology 09/1997
  • Han B, Klonowski-Stumpe H, Sata N, Lüthen R, Schliess F, Häussinger D, Niederau C - Cell volume changes modulate cholecystokinin and carbachol stimulated amylase release in isolated rat pancreatic acini. Gastroenterology 05/1997 1756-1766
  • von Herbay A, Stahl W, Niederau C, Sies H - Vitamin E improves the aminotransferase status of patients suffering from viral hepatitis C: a randomized, double-blind, placebo-controlled study. Free Radic Res 10/1997 599-605
  • von Herbay A, Frieling T, Niederau C, Haussinger D - Solitary hepatic lesions with a hypoechoic rim: value of color Doppler sonography. American Journal of Roentgenology 04/1998
  • Mohr L, Heintges T, Hensel F, Niederau C, Haussinger D - Treatment of autoimmune cholangitis. Digestive Diseases and Sciences 08/1998 2160-2163
  • vom Dahl S, Harzer K, Rolfs A, Albrecht B, Niederau C, Vogt C, van Weely S, Aerts J, Muller G, Häussinger D - Hepatosplenomegalic lipidosis: what unless Gaucher? Adult cholesteryl ester storage disease (CESD) with anemia, mesenteric lipodystrophy, increased plasma chitotriosidase activity and a homozygous lysosomal acid lipase -1 exon 8 splice junction mutation. Journal of Hepatology 04/1999 741-746
  • Erhardt A, Reineke U, Blondin D, Gerlich WH, Adams O, Heintges T, Niederau C, Häussinger D - Mutations of the core promoter and response to interferon treatment in chronic replicative hepatitis B. . Hepatology 11/2000 716-725
  • Poll LW, Koch JA, vom Dahl S, Loxtermann E, Sarbia M, Niederau C, Häussinger D, Mödder U - Extraosseous manifestation of Gaucher's disease type I: MR and histological appearance. European Journal of Radiology 02/2000 861-869
  • Heintges T, Petry W, Kaldewey M, Erhardt A, Wend UC, Gerlich WH, Niederau C, Häussinger D. - Combination therapy of active HBsAg vaccination and interferon-alpha in interferon-alpha nonresponders with chronic hepatitis B. Digestive Diseases and Sciences 05/2001 901-906
  • Erhardt A, Maschner-Olberg A, Mellenthin C, Kappert G, Adams O, Donner A, Willers R, Niederau C, Häussinger D - HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis. Journal of Hepatology 03/2003 335-343
  • Niederau C, Fischer R, Sonnenberg A, Stremmel W, Trampisch HJ, Strohmeyer G: - Survival and causes of death in primary hemochromatosis. . New England Journal of Medicine 03/1996 281-291
  • Witthöft T, Möller B, Wiedmann KH, Mauss S, Link R, Lohmeyer J, Lafrenz M, Gelbmann CM, Hüppe D, Niederau C, Alshuth U. - Safety, tolerability and efficacy of peginterferon alpha-2a and ribavirin in chronic hepatitis C in clinical practice. Journal of Viral Hepatitis 11/2007 788-796
  • Phatak P, Brissot P, Wurster M, Adams PC, Bonkovsky HL, Gross J, Malfertheiner P, McLaren - A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron . Hepatology 11/2011 1671-1679
  • Poynard T, Marcellin P, Lee SS, Niederau C, Minuk GS, Ideo G, Bain V, Heathcote J, Zeuzem S, Trepo C, Albrecht J. - Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group. Lancet 09/1998 1426-1432
  • Lüthen R, Ferrell LD, Grendell JH, Niederau C - Intrapancreatic activation of digestive zymogens during caerulein pancreatitis in rats. A possible role for changes in ATP and glutathione levels. American Journal of Physiology 09/1995
  • Biegstraaten M, Mengel E, Maródi L, Petakov M, Niederau C, Giraldo P, Hughes D, Mrsic M, Mehta A, Hollak CE, van Schaik IN - Peripheral neuropathy in adult type 1 Gaucher disease: a 2-year prospective observational study. Brain 03/2010 2909-2919
  • Bruix J, Poynard T, Colombo M, Schiff E, Burak K, Heathcote EJ, Berg T, Poo JL, Mello CB, - A phase 1/2, dose-escalation trial of deferasirox for the treatment of iron . Hepatology 05/2011 1990-1991
  • Biegstraaten M, Wesnes KA, Luzy C, Petakov M, Mrsic M, Niederau C, Giraldo P, Hughes D, Mehta - The cognitive profile of type 1 Gaucher disease . J Inherit Metab Di 10/2012 1093-1099
  • Buster EHCJ, Hansen BE, Buti M, Delwaide J, Niederau C, et al. - PEGInterferon alpha-2b is safe and effective in HBeAg positive chronic hepatitis B patients with adva. Hepatology 04/2007
  • Niederau C, Grendell JH, Rothman SS. - Effects of proglumide on ductal and basolateral secretion of pancreatic digestive enzymes.. American Journal of Physiology 07/1985
  • Niederau C, Liddle RA, Ferrell LD, Grendell JH. - Beneficial effects of CCK-receptor blockade and inhi-bition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice: evidence for cholecy¬stokinin as a major factor in the development of acute pancreatitis. Journal of Clinicical Investigation 05/1996 1056-1063
  • Niederau C, Grendell JH, Rothman SS. - Digestive end products release pancreatic enzymes from particulate cellular pools, particularly zymogen granules. Biochim Biophysica Acta 02/1997 281-291
  • Heintges T, Mohr L, Hensel F, Petry W, Borchard F, Häussinger D, Niederau C - Value of liver biopsy prior to interferon therapy for chronic viral hepatitis. Digestive Diseases and Sciences 02/1998 1562-1565
  • Flamm SL, Lawitz E, Jacobson I, Bourlière M, Hezode C, Vierling JM, Bacon BR, Niederau C, - Boceprevir With Peginterferon Alfa-2a-Ribavirin Is Effective for Previously Treated Chronic Hepatitis C Genotype 1 Infection. Clinical Gastroenterology and Hepatology 02/2013 81-87
  • Yildiz Y, Hoffmann P, vom Dahl S, Breiden B, Sandhoff R, Niederau C, Horwitz M, Karlsson S, - Functional and genetic characterization of the non-lysosomal . Orphanet Journal of Rare Diseases 07/2013 151-160
  • Arama V, Hakan Leblebicioglu H, Krzysztof Simon K, Jean Pierre Zarski JP, Niederau C - Chronic hepatitis B monitoring and treatment patterns in five European countries with . Antiviral Therapy 02/2014
  • Niederau C, Strohmeyer G: - Hemochromatosis. Conn's current therapy, 39th Edition. Saunders Company, Philadelphia 1987 07/1986 117-148
  • Niederau C, Müller J, Sonnenberg A, Scholten T, Erckenbrecht J, Fritsch WP, Brüster T, Strohmeyer G - Extrahepatic bile ducts in healthy subjects, in patients with cholelithiasis and in postcholecystectomy patients. Journal of Clinical Ultrasound 02/1983 23-27
  • Niederau C - Morbus Gaucher diagnostizieren und behandeln. Thieme Refresher Innere Medizin 02/2013 1-16